Daily Archives: August 13, 2018

Bombardier Continues African Market Penetration with Pre-Owned Q400

  • PassionAir becomes first Bombardier operator in Ghana with three Q400 aircraft

MONTREAL, Aug. 13, 2018 (GLOBE NEWSWIRE) — Bombardier Commercial Aircraft announced today that the company successfully placed three pre-owned Q400 turboprops with PassionAir from the Republic of Ghana. The airline acquired the aircraft through a dry-lease with a third party.DDBC0480_Q400_PassionAir_10X8

“Bombardier has sold about 3,500 new regional aircraft to date, and we continue to be very active on the used aircraft market.” said David Speirs, Vice President, Asset Management, Bombardier Commercial Aircraft. “Our recent momentum on the pre-owned aircraft market worldwide is a clear indication that our products are addressing a growing need for regional air transportation, especially in emerging markets.”

“Our market penetration in Africa continues to intensify, and we are pleased to welcome Passion Air as the first commercial airline operating a Bombardier regional aircraft in the Republic of Ghana,” said Jean-Paul Boutibou, Vice President, Sales, Middle East and Africa, Bombardier Commercial Aircraft. “Africa is the youngest and fastest growing region in the world, and regional aircraft like the Q400 will play a key role in helping advancing Africa’s economic growth.”

The airline will operate the three Q400 aircraft in a 78-seat configuration on domestic routes.

“This is a first step, and we look forward to expanding our fleet with more Bombardier aircraft,” said Edward Annan, Chief Executive Officer, PassionAir. “The Q400 offers the performance and flexibility that we need to further develop our network. With a range that unlocks great opportunities for us, we are confident that we will capitalize on a larger market, which extends to 12 countries and over 180 million potential passengers out of Accra.”

About PassionAir
PassionAir is a Ghanaian owned airline, and aims to become the most competitive Aviation Service Provider in Ghana and West Africa. Our focus is on safety and excellent customer service delivery, depicting the proverbial Ghanaian hospitality. Our product lines range from scheduled to chartered flights offered at internationally accepted standards and competitive prices.

PassionAir as start off, will operate flights domestically, with plans of expanding our services to the West African sub-region in the medium term.

About Bombardier
With over 69,500 employees across four business segments, Bombardier is a global leader in the transportation industry, creating innovative and game-changing planes and trains. Our products and services provide world-class transportation experiences that set new standards in passenger comfort, energy efficiency, reliability and safety.

Headquartered in Montreal, Canada, Bombardier has production and engineering sites in 28 countries across the segments of Transportation, Business Aircraft, Commercial Aircraft and Aerostructures and Engineering Services. Bombardier shares are traded on the Toronto Stock Exchange (BBD). In the fiscal year ended December 31, 2017, Bombardier posted revenues of $16.2 billion US. News and information are available at bombardier.com or follow us on Twitter @Bombardier.

Notes to Editors
To receive our press releases, please visit the RSS Feed section.

Pictures of the Q Series aircraft are available on www.bombardier.com.

For more information about Bombardier Commercial Aircraft, visit http://commercialaircraft.bombardier.com/.

Bombardier, Q Series, Q400 are trademarks of Bombardier Inc. and its affiliates.

For Information

Nathalie Siphengphet
Head of Communications and Public Relations
Bombardier Commercial Aircraft
+1 416-375-3030
nathalie.siphengphet@aero.bombardier.com

www.bombardier.com

A photo accompanying this announcement is available at http://www.globenewswire.com/NewsRoom/AttachmentNg/a7a12071-57c0-4623-a95c-2fea00764cb9

Checkpoint Therapeutics Announces Clinical Data on EGFR Inhibitor CK-101 Selected for Late-Breaking Oral Presentation at IASLC 19th World Conference on Lung Cancer

NEW YORK, Aug. 13, 2018 (GLOBE NEWSWIRE) — Checkpoint Therapeutics, Inc. (“Checkpoint”) (NASDAQ: CKPT), a clinical-stage immuno-oncology biopharmaceutical company focused on the acquisition, development and commercialization of novel treatments for patients with solid tumor cancers, today announced that preliminary safety and efficacy data from a Phase 1/2 clinical trial of CK-101 (also known as RX518), a third-generation epidermal growth factor receptor (“EGFR”) tyrosine kinase inhibitor (“TKI”) being evaluated in advanced non-small cell lung cancer, has been selected for a late-breaking oral presentation at the International Association for the Study of Lung Cancer (IASLC) 19th World Conference on Lung Cancer, to be held September 23-26, 2018, in Toronto.

“We are thrilled to announce that preliminary data from the Phase 1/2 trial of our novel third-generation EGFR inhibitor has been selected for a late-breaking oral presentation at the World Conference on Lung Cancer. This marks the first clinical data to be reported by Checkpoint, an important clinical and corporate milestone,” said James F. Oliviero, President and Chief Executive Officer of Checkpoint Therapeutics. “Third-generation EGFR inhibitors are highly selective and have the potential to demonstrate improved safety and tolerability versus earlier-generation therapies. There is currently only one third-generation EGFR inhibitor approved and we believe CK-101 could be second to market potentially with a differentiated safety profile.”

Details of the presentation are as follows:

Title: CK-101 (RX518), a Third Generation Mutant-Selective Inhibitor of EGFR in NSCLC: Results of an Ongoing Phase I/II Trial
Date: Monday, Sept. 24, 2018
Session: Novel Therapies in ROS1, HER2 and EGFR
Presenter: Melissa L. Johnson, M.D., Associate Director, Lung Cancer Research, Sarah Cannon Research Institute at Tennessee Oncology, PLLC, Nashville, Tenn.

The full abstract will be posted on the conference website on Wednesday, Sept. 5, 2018, at 5 p.m. ET. For additional information, please visit: https://wclc2018.iaslc.org/#.

Checkpoint holds an exclusive worldwide license (except with respect to certain Asian countries) to CK‐101, which it acquired from NeuPharma, Inc. in 2015.

About CK-101
CK-101 (also known as RX518) is an oral, third-generation, irreversible kinase inhibitor against selective mutations in the EGFR gene. Activating mutations in the tyrosine kinase domain of EGFR, such as L858R and exon 19 deletion, are found in approximately 20 percent of patients with advanced non-small cell lung cancer (“NSCLC”).

Compared to chemotherapy, first-generation EGFR inhibitors significantly improved objective response rate and progression-free survival in previously untreated NSCLC patients carrying EGFR mutations. However, tumor progression could develop due to resistance mutations, often within months of treatment with first-generation EGFR inhibitors. The EGFR T790M “gatekeeper” mutation is the most common resistance mutation found in patients treated with first-generation EGFR inhibitors. The mutation decreases the affinity of first-generation inhibitors to EGFR kinase domain, rendering the drugs ineffective. Second-generation EGFR inhibitors have improved potency against the T790M mutation, but have not provided meaningful benefits in NSCLC patients due to toxicity from also inhibiting wild-type EGFR. Third-generation EGFR inhibitors are designed to be highly selective against both EGFR-TKI-sensitizing and resistance mutations, with minimal activity on wild-type EGFR, thereby improving tolerability and safety profiles.

Checkpoint Therapeutics is developing CK-101 for the treatment of NSCLC patients carrying the susceptible EGFR mutations. These include the EGFR T790M mutation in second-line NSCLC patients, as well as the EGFR L858R and exon 19 deletion mutations in first-line NSCLC patients.

About Checkpoint Therapeutics
Checkpoint Therapeutics, Inc. (“Checkpoint”) is a clinical-stage, immuno-oncology biopharmaceutical company focused on the acquisition, development and commercialization of novel treatments for patients with solid tumor cancers. Checkpoint is evaluating its lead small-molecule, targeted anti-cancer agent, CK-101, in a Phase 1/2 clinical trial for the treatment of patients with EGFR mutation-positive non-small cell lung cancer (“NSCLC”). In addition, Checkpoint is currently evaluating its lead antibody product candidate, CK-301, an anti-PD-L1 antibody licensed from the Dana-Farber Cancer Institute, in a Phase 1 clinical trial in checkpoint therapy-naïve patients with selected recurrent or metastatic cancers. Checkpoint plans to develop CK-301 as a treatment for patients with NSCLC and other solid tumors. Checkpoint is a majority-controlled subsidiary of Fortress Biotech, Inc., and is headquartered in New York City. For more information, visit www.checkpointtx.com.

About Fortress Biotech
Fortress Biotech, Inc. (“Fortress”) (NASDAQ: FBIO) is a biopharmaceutical company dedicated to acquiring, developing and commercializing novel pharmaceutical and biotechnology products. Fortress develops and commercializes products both within Fortress and through certain of its subsidiary companies, also known as Fortress Companies. In addition to its internal development programs, Fortress leverages its biopharmaceutical business expertise and drug development capabilities and provides funding and management services to help the Fortress Companies achieve their goals. Fortress and the Fortress Companies may seek licensing arrangements, acquisitions, partnerships, joint ventures and/or public and private financings to accelerate and provide additional funding to support their research and development programs. For more information, visit www.fortressbiotech.com.

Forward‐Looking Statements
This press release may contain “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, each as amended. Such statements include, but are not limited to, any statements relating to our growth strategy and product development programs, and any other statements that are not historical facts. Forward-looking statements are based on management’s current expectations and are subject to risks and uncertainties that could negatively affect our business, operating results, financial condition and stock value. Factors that could cause actual results to differ materially from those currently anticipated include: risks relating to our growth strategy; our ability to obtain, perform under and maintain financing and strategic agreements and relationships; risks relating to the results of research and development activities; risks relating to the timing of starting and completing clinical trials; uncertainties relating to preclinical and clinical testing; our dependence on third-party suppliers; our ability to attract, integrate and retain key personnel; the early stage of products under development; our need for substantial additional funds; government regulation; patent and intellectual property matters; competition; as well as other risks described in our SEC filings. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions or circumstances on which any such statement is based, except as required by law.

Company Contact:
Jaclyn Jaffe
Checkpoint Therapeutics, Inc.
(781) 652-4500
ir@checkpointtx.com

Investor Relations Contact:
Jeremy Feffer
Managing Director, LifeSci Advisors, LLC
(212) 915-2568
jeremy@lifesciadvisors.com

Media Relations Contact:
Laura Bagby
6 Degrees
(312) 448-8098
lbagby@6degreespr.com

ATPCO Awarded Patent for Cacheless Airline Ticket Pricing Model

Establishes Technology Foundational to Next-Gen Airline Revenue Management Tools

DULLES, Va., Aug. 13, 2018 (GLOBE NEWSWIRE) — ATPCO today announced that it has been awarded Patent #10,032,195 by the United States Patent and Trademark Office to cover new technology, developed by its data scientists and technical architects, that enables construction of airline ticket prices using graph database and “functional programming” techniques. This technology permits a unique approach to calculating airfare prices that was not previously available.

Airline ticket prices are built using diverse individual data components: fares, flight schedules, taxes, and various legal and governance structures. An airline also sets business restrictions, known as rules, to determine under what circumstances a fare may be offered, such as requiring a Saturday-night stay or during pre-determined promotional sale dates. All these elements must be referenced and incorporated into the final price of an airline ticket. The pricing approach covered by this patent enables ATPCO to generate all published prices globally, in real time, independent of availability. This will give carriers and airline channel partners a total view of all prices that make up a market.

“This approach maintains all the links to the original data components that make up a total airline ticket price. Therefore, we can deconstruct a price into all its components once it’s generated, as well as identify all the rule provisions that made the price eligible. This has tremendous advantages for the pricing and audit capabilities that we are pursuing,” said John Murphy, Vice President of Technology at ATPCO.

Unlike traditional pricing engines used today to sell tickets that focus on calculating the lowest or “best” fare in the marketplace, ATPCO’s approach was engineered to support airline revenue management and pricing departments that manage all the various price points an airline wants to offer.

“To support these needs, pricing engines need to calculate prices for all possible fares (not just the lowest) and to keep track of all the components that made up the price without relying on cached results. Cached results can become outdated quickly, which creates problems when an airline pricing analyst wants to make changes or audit how or why a particular price was made available,” said Navid Abbassi, Chief Architect at ATPCO.

Detecting when elements change, testing how scenarios will price, and validating fares before they are distributed are enabled by this technology, which is part of ATPCO’s commitment to lead the airline industry into the next generation of distribution.

Through the speed and scalability of the approach enabled by this work, millions of pricing responses can be processed and generated in real time without losing the context of the data that created those prices in the first place. By making it easier to change elements of a ticket price, ATPCO is giving airlines new and more efficient ways to manage their price points offered in any given market.

Follow ATPCO:
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For further information contact:

Michael Mazzocco
Corporate Communications Strategist
ATPCO
Office: +1 703 661 7503
Email: mmazzocco@atpco.net

About ATPCO

Uniquely positioned at the center of the airline distribution ecosystem, ATPCO enables seamless management of the airfare data that makes our entire industry run more efficiently. We hold more than 189.6 million fares for 439 airlines in 160 countries and manage an average of 5.3 million daily fare changes. Because ATPCO is owned by airlines, we serve as a neutral and trusted partner for our airlines with travel agencies, search engines, global distribution systems, governments, and many other industry partners. Every day, these organizations rely on our thought leadership and portfolio of technology and data solutions to help millions of travelers get where they need to go. Learn more about us at atpco.net.

Young volunteers aid socio-economic growth

More than 2 million young people have taken part in volunteer movements over the past 25 years, according to a Sunday ceremony to mark the 25th anniversary of Ho Chi Minh City’s Youth Union Summer Volunteer Campaigns.

The young volunteers have eliminated illiteracy for 29,000 people, planted more than 3 million trees, upgraded more than 600km of roads, and built or repaired 450 rural bridges, cultural houses, and schools. The movements have targeted the Central Highlands, the central coasts, border areas, and Laos and Cambodia.

Our young volunteer campaigns have grown year after year, dedicating youthful strength to projects like building new rural areas, improving urban areas, and environmental protection. The young volunteers have formed close relationships with local people, said Ngo Minh Hai, Vice Secretary of the Ho Chi Minh City Youth Union.

This year, the Ho Chi Minh City Youth Union was awarded the Labor Order, 3rd class.

Source: VOV5

Vietnam emerges as Asia’s newest ‘tiger’ economy: QNB

The Qatar National Bank (QNB) has noted that Vietnam is Asia’s latest tiger, as it emerges as one of the world’s fastest growing economies.

A range of indicators are proof-positive of Vietnam’s booming economy, according to QNB’s weekly economic commentary. GDP growth raced ahead by 7.1 percent in the first six months of 2018; the economy’s fastest growth since 2011. The manufacturing sector is leading the charge with output up 13.1 percent in the first half of the year.

Manufacturing and export successes have been driven by Vietnam’s ability to attract large foreign direct investment (FDI) inflows into sectors such as clothing, footwear, and above all, electronics, QNB said. The latest data shows FDI inflows are also booming, with an estimated value of 13 billion USD in the first half of this year, an 11 percent growth.

The bank attributed Vietnam’s success to favourable demographics, low wage rates, political stability, and geography.

Source: VOV5

Vietnam ranks 2nd in GI protection in Southeast Asia

Geographical indication (GI) registration contributes to the increasing value of farm produce, helping farmers to gain more profit.

Up to July 2018, Vietnam’s National Office of Intellectual Property has recognized 62 geographical indications inside Vietnam and 6 geographical indications abroad. 37 cities and provinces have had their geographical indications protected as a result.

“Vietnam ranks 2nd in Southeast Asia in terms of geographical indication registration, just after Thailand. However, our GI registration abroad is still limited, and this step is very important in order to protect our markets overseas. It’s necessary to provide timely instructions and support for localities with special farm produce, in registering GI for their products both at home and abroad, said Ta Quang Minh, Head of Vietnam’s Intellectual Property Research Institute under the Ministry of Science and Technology.

Vietnam boasts nearly 1,000 special farm products nationwide.

Source: VOV5

Vietnam consistantly pursues comprehensive, creative diplomacy

Deputy Prime Minister and Foreign Minister Pham Binh Minh said Vietnam’s proactive and flexible diplomatic policies have yielded significant results.

Mr. Minh made the remark at the 30th Diplomatic Conference in Hanoi on Monday, attended by Party leader Nguyen Phu Trong, President Tran Dai Quang, Prime Minister Nguyen Xuan Phuc, and National Assembly Chairwoman Nguyen Thi Kim Ngan.

Vietnam has fulfilled external affairs goals set by the 12th Party Congress. They included taking advantage of external resources for development and protecting national independence and territorial integrity while maintaining a peaceful and sustainable environment, said Deputy PM Minh.

Vietnam has established strategic and comprehensive partnerships with 27 countries, signed 16 free trade agreements, and held many important positions in the UN and other multilateral organizations.

Party leader Nguyen Phu Trong said the diplomatic sector’s achievements in all fields over the past 2 years have strengthened public trust and created a strong consensus of approval of the leadership of the Party and State.

Mr. Trong called on the sector to seize every opportunity to prosper despite the world’s complex changes.

We must not be complacent about the progress so far because we still have lots of things to do. It’s necessary to review and draw lessons from what we have done to see whether or not we have missed any opportunities. We should check possible bottle necks in our relationships with major partners and decide whether or not the signed framework documents have created the intended benefits. The 12th National Party Congress’ assessment of the world situation is important, so we must keep a close eye on global changes and react to perceived risks, he noted

Mr. Trong asked the diplomatic sector to continuously renew the current way of thinking, consistently follow a diplomatic policy of independence and self-reliance, maximize all favorable factors, and improve relations with neighbors and traditional partners.

He underscored the importance of implementing trade agreements, improving economic diplomacy, strengthening coordination between ministries, sectors, and localities, and most importantly, focusing on strategic forecast.

Source: VOV5